MUC7

Across TCGA pan-cancer cohorts, MUC7 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MUC7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MUC7 RNA is repressed in tumor relative to normal tissue. In most cancer types MUC7 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, BRCA, and UCEC are the cancer types where MUC7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MUC7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−3.771	<.001	10	view →
BRCA	Female	All	−0.643	<.001	4	view →
UCEC	All	All	+0.144	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MUC7–HNSC

Open the HNSC breakdown →