MUC7

Across TCGA patient cohorts, MUC7 mutation is significantly associated with the RNA expression of many other genes, with 2,298 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC7-associated genes across cancer lineages are MRPS5, SLC25A4, and ZNF77. Each is linked with MUC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC7-to-partner and partner-to-MUC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5 grouped by MUC7-low versus MUC7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC7→partner) and Y-score (partner→MUC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS5 →	+0.274	+1.669	.006	.007	3	3
UCEC	SLC25A4 →	+0.656	+3.711	<.001	<.001	3	3
UCEC	ZNF77 →	+0.514	+2.823	<.001	.001	3	3
CESC	KRTAP4-4 →	+0.203	+5.201	<.001	.007	3	2
CESC	LINC00434 →	+0.305	+5.103	<.001	.008	3	2
CESC	SS18L2P1 →	+0.255	+5.306	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,298 associations by consensus.

MRPS5 by MUC7 expression — SKCM

Explore this box plot interactively →