MUC7

Across TCGA patient cohorts, MUC7 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC7-associated genes across cancer lineages are Cyclin-B1, XRCC1, and 14-3-3_beta. Each is linked with MUC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC7-to-partner and partner-to-MUC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MUC7-low versus MUC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC7→partner) and Y-score (partner→MUC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.802	+3.584	<.001	.002	3	3
LUAD	XRCC1 →	+0.176	+3.000	.029	.036	3	2
UCEC	14-3-3_beta →	-0.132	-2.558	.001	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-2.321	.007	.034	3	2
UCEC	CD49b →	-0.294	-1.980	.010	.030	3	2
SKCM	Bap1-c-4 →	+0.247	+1.906	.042	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Cyclin-B1 by MUC7 expression — UCEC

Explore this box plot interactively →