Across TCGA cell cohorts, MUC6 mutation is significantly associated with the RNA expression of many other genes, with 423 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC6-associated genes across cancer lineages are OPN1MW2, TBC1D15, and TAF5. Each is linked with MUC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC6-to-partner and partner-to-MUC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC6→partner) and Y-score (partner→MUC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OPN1MW2 →	+0.382	+4.058	<.001	.007	3	2
BLOOD_Leukemia	TBC1D15 →	+0.562	+2.614	.002	.003	3	2
BLOOD_Leukemia	TAF5 →	+0.450	+3.115	.005	.009	3	2
BLOOD_Leukemia	RNF144A →	+1.418	+3.459	.001	.002	3	2
BLOOD_Leukemia	USP17L2 →	+0.066	+2.344	<.001	.001	3	2
LUNG_NSCLC_LUAD	MYH7 →	+0.008	+3.887	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 423 associations by consensus.

Exploration

MUC6 survival (RNA) · tumor vs normal (RNA) · all MUC6 data types