MUC5B

Across TCGA pan-cancer cohorts, MUC5B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MUC5B data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MUC5B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MUC5B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where MUC5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.557	0.951	<.001	72	view →
LUAD	DFS	Tertile	All	0.750	0.974	.004	31	view →
UCEC	DFS	Quartile	All	1.000	0.773	.001	22	view →
GBM	DFS	Tertile	All	0.228	0.461	.009	7	view →
CCRCC	DFS	Median	III,IV	0.917	0.444	.010	6	view →
HNSC	OS	Tertile	III,IV	1.000	0.331	.040	4	view →
LSCC	DFS	Tertile	II,III,IV	0.869	0.983	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MUC5B–PDAC (OS)

Open the PDAC breakdown →