MUC5B

Across TCGA pan-cancer cohorts, MUC5B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MUC5B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MUC5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MUC5B is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

LUAD, HNSC, and PAAD are the cancer types where MUC5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MUC5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+3.199	<.001	8	view →
HNSC	All	All	−2.059	<.001	7	view →
PAAD	All	All	+4.080	.005	4	view →
BRCA	Female	All	+0.954	<.001	4	view →
ESCA	All	All	+2.635	.024	3	view →
STAD	All	All	+2.033	.005	3	view →
KICH	All	II,III,IV	+0.017	.007	3	view →
UCEC	All	III,IV	+2.648	.020	2	view →
LUSC	All	All	−0.851	.028	2	view →
LUSC	Female	III,IV	+2.204	.022	1	view →
LIHC	Female	All	+1.177	.038	1	view →
KIRC	Male	All	+0.013	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

MUC5B–LUAD

Open the LUAD breakdown →