MUC5B

Across TCGA patient cohorts, MUC5B protein abundance is significantly associated with the RNA expression of many other genes, with 10,698 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MUC5B-associated genes across cancer lineages are TFF3, SPDEF, and BPIFB2. Each is linked with MUC5B in more than 6 cancer types. Because this analysis shows association rather than direction, both MUC5B-to-partner and partner-to-MUC5B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MUC5B versus TFF3 in HNSC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC5B→partner) and Y-score (partner→MUC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TFF3 →	+3.014	+1.594	<.001	<.001	3	7
BRCA	SPDEF →	+1.841	+1.132	<.001	.001	3	7
HNSC	BPIFB2 →	+2.757	+1.170	<.001	<.001	3	6
BRCA	TMC5 →	+1.521	+0.975	<.001	<.001	3	5
BRCA	AGR2 →	+2.407	+1.218	.004	.004	2	6
BRCA	GNA14 →	+0.872	+0.911	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,698 associations by consensus.

MUC5B vs TFF3 — HNSC

Explore this scatter interactively →