MUC5B

Across TCGA patient cohorts, MUC5B mutation is significantly associated with the total protein of many other genes, with 123 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MUC5B-associated genes across cancer lineages are mTOR_pS2448, 4E-BP1, and eEF2. Each is linked with MUC5B in more than 6 cancer types. Because this analysis shows association rather than direction, both MUC5B-to-partner and partner-to-MUC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MUC5B-low versus MUC5B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC5B→partner) and Y-score (partner→MUC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.197	-1.572	<.001	.016	3	7
STAD	4E-BP1 →	+0.240	+2.058	.005	<.001	3	6
SARC	eEF2 →	+0.311	+3.000	.009	.031	3	6
COAD	ATM →	-0.439	-1.807	<.001	.002	3	6
LUAD	Chk1 →	+0.277	+1.353	<.001	.014	3	5
STAD	Bad_pS112 →	-0.194	-3.906	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

mTOR_pS2448 by MUC5B expression — LUAD

Explore this box plot interactively →