MUC5B

Across TCGA cell cohorts, MUC5B mutation is significantly associated with the RNA expression of many other genes, with 4,146 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MUC5B-associated genes across cancer lineages are AAAS, TCF20, and EPSTI1. Each is linked with MUC5B in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC5B-to-partner and partner-to-MUC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AAAS grouped by MUC5B-low versus MUC5B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC5B→partner) and Y-score (partner→MUC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AAAS →	+0.375	+3.310	.001	.007	3	5
BLOOD_Leukemia	TCF20 →	+0.513	+2.199	.001	<.001	3	5
PANCREAS	EPSTI1 →	-1.288	-2.528	.002	.003	3	4
BLOOD_Leukemia	C12orf65 →	+0.538	+2.222	<.001	.003	3	4
CNS	DYNLT1 →	-0.478	-3.700	.005	<.001	3	4
BLOOD_Leukemia	NPHP4 →	+0.599	+2.199	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,146 associations by consensus.

AAAS by MUC5B expression — CNS

Explore this box plot interactively →