Across TCGA pan-cancer cohorts, MUC5AC Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MUC5AC data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MUC5AC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUC5AC expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.
HNSC, LUAD, and UCEC are the cancer types where MUC5AC Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.