Across TCGA pan-cancer cohorts, MUC5AC RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MUC5AC’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MUC5AC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MUC5AC is over-expressed in tumor.
COAD, UCEC, and PAAD are the cancer types where MUC5AC tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MUC5AC RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.