Across TCGA patient cohorts, MUC5AC mutation is significantly associated with the RNA expression of many other genes, with 4,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC5AC-associated genes across cancer lineages are ALPL, KIF2C, and UBE2S. Each is linked with MUC5AC in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC5AC-to-partner and partner-to-MUC5AC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC5AC→partner) and Y-score (partner→MUC5AC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ALPL →	-1.224	-1.938	.001	.001	3	5
LUAD	KIF2C →	+0.827	+1.663	<.001	.003	3	5
UCEC	UBE2S →	+0.651	+3.108	<.001	<.001	3	4
UCEC	MRTO4 →	+0.344	+2.050	<.001	<.001	3	4
UCEC	GNL3 →	+0.391	+3.043	.002	<.001	3	4
COAD	SNRPD1 →	+0.588	+3.335	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,909 associations by consensus.

Exploration

MUC5AC survival (RNA) · tumor vs normal (RNA) · all MUC5AC data types