Across TCGA cell cohorts, MUC5AC mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC5AC-associated genes across cancer lineages are DMRTB1, OR1L6, and OR1L3. Each is linked with MUC5AC in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC5AC-to-partner and partner-to-MUC5AC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC5AC→partner) and Y-score (partner→MUC5AC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1L3 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2T12 →	+0.032	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+4.887	.009	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.032	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

MUC5AC survival (RNA) · tumor vs normal (RNA) · all MUC5AC data types