MUC4

Across TCGA cell cohorts, MUC4 mutation is significantly associated with the RNA expression of many other genes, with 1,653 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC4-associated genes across cancer lineages are FANCD2, NEK4, and EAF1. Each is linked with MUC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC4-to-partner and partner-to-MUC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCD2 grouped by MUC4-low versus MUC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC4→partner) and Y-score (partner→MUC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FANCD2 →	+0.565	+1.765	<.001	<.001	3	5
LARGE_INTESTINE	NEK4 →	+0.596	+1.847	<.001	<.001	3	4
LARGE_INTESTINE	EAF1 →	+0.494	+1.227	<.001	<.001	3	4
LUNG_SCLC	USP19 →	+0.440	+1.662	.005	<.001	3	4
LUNG_SCLC	ARIH2 →	+0.391	+2.700	.001	<.001	3	4
BREAST	GPR143 →	+1.030	+1.700	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,653 associations by consensus.

FANCD2 by MUC4 expression — LARGE_INTESTINE

Explore this box plot interactively →