MUC3A

Across TCGA patient cohorts, MUC3A mutation is significantly associated with the RNA expression of many other genes, with 2,597 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC3A-associated genes across cancer lineages are SIVA1, ATF4P3, and PES1. Each is linked with MUC3A in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC3A-to-partner and partner-to-MUC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIVA1 grouped by MUC3A-low versus MUC3A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC3A→partner) and Y-score (partner→MUC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SIVA1 →	+0.435	+3.768	.001	<.001	3	3
UCEC	ATF4P3 →	+0.416	+2.217	<.001	.001	3	3
UCEC	PES1 →	+0.437	+2.523	.003	<.001	3	2
SKCM	PPP6R2 →	+0.374	+3.398	.001	<.001	3	2
SKCM	SBF1 →	+0.405	+1.867	.009	.005	3	2
SKCM	LMF2 →	+0.503	+2.292	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,597 associations by consensus.

SIVA1 by MUC3A expression — SKCM

Explore this box plot interactively →