MUC3A

Across TCGA pan-cancer cohorts, MUC3A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MUC3A data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MUC3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MUC3A expression acts as an unfavorable survival marker, although some lineages such as LUSC and THCA show a favorable association.

KIRC, MESO, and BRCA are the cancer types where MUC3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.309	0.553	.001	56	view →
MESO	OS	Quartile	All	0.239	0.545	<.001	53	view →
BRCA	OS	Median	IV	0.353	0.793	.002	45	view →
UVM	DFS	Median	II,III,IV	0.418	0.716	<.001	45	view →
LGG	DFS	Tertile	All	0.653	0.808	<.001	41	view →
ACC	DFS	Tertile	III,IV	0.281	0.965	.008	32	view →
UCEC	OS	Tertile	All	0.899	0.957	<.001	26	view →
UCS	DFS	Tertile	All	0.372	0.719	.004	24	view →
LUSC	OS	Tertile	II,III,IV	0.958	0.611	.002	24	view →
THCA	DFS	Tertile	IV	1.000	0.750	.012	17	view →
KIRP	DFS	Tertile	All	0.962	0.839	.012	17	view →
COAD	DFS	Median	IV	0.243	0.642	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MUC3A–KIRC (DFS)

Open the KIRC breakdown →