MUC3A

Across TCGA patient cohorts, MUC3A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC3A-associated genes across cancer lineages are PCNA, 4E-BP1, and Cyclin-B1. Each is linked with MUC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC3A-to-partner and partner-to-MUC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MUC3A-low versus MUC3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC3A→partner) and Y-score (partner→MUC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.307	+3.700	<.001	.001	3	2
UCEC	4E-BP1 →	+0.488	+2.936	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.925	+3.247	<.001	<.001	3	2
UCEC	FoxM1 →	+0.365	+2.584	<.001	.001	3	1
UCEC	MEK1 →	+0.536	+3.247	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.165	-2.787	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by MUC3A expression — UCEC

Explore this box plot interactively →