MUC3A

Across TCGA cell cohorts, MUC3A mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MUC3A-associated genes across cancer lineages are CPXCR1, PROP1, and G6PC2. Each is linked with MUC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC3A-to-partner and partner-to-MUC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by MUC3A-low versus MUC3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC3A→partner) and Y-score (partner→MUC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPXCR1 →	+0.079	+3.886	<.001	.002	3	2
BLOOD_Leukemia	PROP1 →	+0.035	+3.704	<.001	.001	3	2
LARGE_INTESTINE	G6PC2 →	+0.027	+3.099	.001	.004	3	2
LARGE_INTESTINE	CXorf51A →	+0.105	+2.657	<.001	.007	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	ZNF716 →	+0.016	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

CPXCR1 by MUC3A expression — BLOOD_Leukemia

Explore this box plot interactively →