MUC20

Across TCGA patient cohorts, MUC20 mutation is significantly associated with the RNA expression of many other genes, with 809 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC20-associated genes across cancer lineages are SNORD105B, RNA5SP421, and RNA5SP423. Each is linked with MUC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC20-to-partner and partner-to-MUC20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD105B grouped by MUC20-low versus MUC20-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC20→partner) and Y-score (partner→MUC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD105B →	+0.252	+2.743	.001	.008	3	2
UCEC	RNA5SP421 →	+0.743	+2.144	<.001	.002	3	2
UCEC	RNA5SP423 →	+0.975	+2.869	<.001	<.001	3	2
UCEC	SNAI3-AS1 →	+0.306	+3.609	.005	.001	3	2
SKCM	MTND2P23 →	+0.068	+4.009	<.001	<.001	3	2
UCEC	BAHD1 →	+0.442	+2.415	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 809 associations by consensus.

SNORD105B by MUC20 expression — SKCM

Explore this box plot interactively →