MUC20

Across TCGA pan-cancer cohorts, MUC20 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MUC20’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MUC20 RNA is repressed in tumor relative to normal tissue. In most cancer types MUC20 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where MUC20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MUC20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−3.088	<.001	12	view →
KIRP	Male	II,III,IV	−3.506	<.001	11	view →
HNSC	All	III,IV	−1.739	<.001	11	view →
THCA	Male	III,IV	+1.571	<.001	9	view →
LUAD	Female	II,III,IV	+2.350	<.001	8	view →
READ	Male	All	−2.686	.031	4	view →
KICH	Female	All	+2.225	.003	3	view →
STAD	Male	All	+1.463	.004	3	view →
CHOL	All	All	+2.718	<.001	2	view →
LUSC	Female	All	+1.799	.002	2	view →
PRAD	All	All	−0.809	<.001	2	view →
COAD	Female	III,IV	−1.025	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MUC20–KIRC

Open the KIRC breakdown →