MUC20-OT1

Across TCGA patient cohorts, MUC20-OT1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC20-OT1-associated genes across cancer lineages are MEK1, p27_pT157, and VEGFR2. Each is linked with MUC20-OT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC20-OT1-to-partner and partner-to-MUC20-OT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MUC20-OT1-low versus MUC20-OT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC20-OT1→partner) and Y-score (partner→MUC20-OT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.480	+3.584	.003	.002	3	1
UCEC	p27_pT157 →	-0.052	-2.986	.047	.035	3	1
UCEC	VEGFR2 →	+0.297	+2.013	.026	.018	3	1
UCEC	ASNS →	+0.355	+3.169	.029	.018	3	1
UCEC	4E-BP1 →	+0.378	+2.489	.001	.010	3	1
UCEC	Cyclin-B1 →	+0.557	+2.000	.027	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by MUC20-OT1 expression — UCEC

Explore this box plot interactively →