Across TCGA patient cohorts, MUC2 mutation is significantly associated with the RNA expression of many other genes, with 8,174 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC2-associated genes across cancer lineages are ZWINT, SDHA, and WDHD1. Each is linked with MUC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MUC2-to-partner and partner-to-MUC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC2→partner) and Y-score (partner→MUC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZWINT →	+0.818	+3.099	.001	<.001	3	6
LUAD	SDHA →	+0.590	+3.816	<.001	<.001	3	6
UCEC	WDHD1 →	+0.625	+1.606	<.001	<.001	3	6
UCEC	CENPO →	+0.465	+1.488	<.001	<.001	3	6
UCEC	CDC7 →	+0.658	+1.477	<.001	<.001	3	6
UCEC	METTL2B →	+0.220	+1.055	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,174 associations by consensus.

Exploration

MUC2 survival (RNA) · tumor vs normal (RNA) · all MUC2 data types