Across TCGA patient cohorts, MUC2 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MUC2-associated genes across cancer lineages are Cyclin-B1, STAT3_pY705, and GSK-3a-b_pS21_S9. Each is linked with MUC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC2-to-partner and partner-to-MUC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC2→partner) and Y-score (partner→MUC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.542	+1.891	.007	.027	3	5
LUAD	STAT3_pY705 →	-0.318	-2.321	.010	.033	3	4
STAD	GSK-3a-b_pS21_S9 →	-0.450	-3.000	.002	.033	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.253	-0.904	.026	.025	3	4
SKCM	4E-BP1_pT70 →	+0.126	+0.875	.010	.037	3	4
STAD	GSK-3_pS9 →	-0.382	-2.459	.018	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

MUC2 survival (RNA) · tumor vs normal (RNA) · all MUC2 data types