Across TCGA cell cohorts, MUC2 mutation is significantly associated with the RNA expression of many other genes, with 3,199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC2-associated genes across cancer lineages are CATSPER3, OR1L3, and RNASEH2C. Each is linked with MUC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC2-to-partner and partner-to-MUC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC2→partner) and Y-score (partner→MUC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CATSPER3 →	+0.418	+2.212	<.001	<.001	3	4
SKIN	OR1L3 →	+0.009	+2.678	<.001	.005	3	3
SKIN	RNASEH2C →	-0.785	-3.541	.001	.001	3	3
BLOOD_Leukemia	ELOA3CP →	+0.081	+1.865	<.001	.008	3	3
LARGE_INTESTINE	RGPD6 →	+0.889	+2.212	<.001	<.001	3	3
LARGE_INTESTINE	CUEDC2 →	+0.603	+2.871	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,199 associations by consensus.

Exploration

MUC2 survival (RNA) · tumor vs normal (RNA) · all MUC2 data types