Across TCGA cell cohorts, MUC19 mutation is significantly associated with the RNA expression of many other genes, with 1,001 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC19-associated genes across cancer lineages are KRTAP2-4, GLYATL3, and PIGY. Each is linked with MUC19 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC19-to-partner and partner-to-MUC19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC19→partner) and Y-score (partner→MUC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP2-4 →	+0.122	+4.930	<.001	.008	3	3
SKIN	GLYATL3 →	+0.006	+2.415	<.001	.009	3	3
LUNG_NSCLC_LUSC	PIGY →	+1.072	+2.938	.002	.001	3	2
OVARY	TRAT1 →	+0.017	+4.029	.005	.009	3	2
LUNG_NSCLC_LUAD	OR52E5 →	+0.050	+2.797	.003	.002	3	2
LUNG_SCLC	EBF3 →	-1.875	-2.352	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,001 associations by consensus.

Exploration

MUC19 survival (RNA) · tumor vs normal (RNA) · all MUC19 data types