MUC16

Across TCGA pan-cancer cohorts, MUC16 Mutation is linked to patient survival in 17 of 34 cancer types, making it a survival-associated MUC16 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MUC16 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated MUC16 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, DLBC, and MESO are the cancer types where MUC16 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.752	0.601	.001	30	view →
DLBC	DFS	Median	All	0.390	0.944	<.001	24	view →
MESO	OS	Median	All	0.171	0.568	<.001	24	view →
SKCM	OS	Median	All	0.817	0.715	<.001	20	view →
BRCA	OS	Median	III,IV	0.170	0.556	.002	19	view →
KIRC	DFS	Median	All	0.678	0.867	.005	18	view →
PCPG	DFS	Median	All	0.074	0.772	<.001	15	view →
UVM	DFS	Median	All	0.032	0.762	<.001	15	view →
ACC	OS	Median	III,IV	0.157	0.482	.012	13	view →
LUSC	DFS	Median	III,IV	0.905	0.421	.006	13	view →
UCS	OS	Median	III,IV	1.000	0.292	.030	12	view →
KIRP	DFS	Median	III,IV	0.040	0.703	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MUC16–UCEC (DFS)

Open the UCEC breakdown →