MUC16

Across TCGA pan-cancer cohorts, MUC16 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MUC16’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MUC16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MUC16 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

LUAD, BLCA, and PAAD are the cancer types where MUC16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MUC16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.838	<.001	9	view →
BLCA	All	All	+0.759	.004	5	view →
PAAD	All	All	+2.405	.012	4	view →
BRCA	All	IV	−1.480	.013	2	view →
STAD	All	All	+0.635	.032	1	view →
LUSC	Female	III,IV	+0.180	.015	1	view →
CHOL	Female	All	+0.020	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MUC16–LUAD

Open the LUAD breakdown →