MUC16

Across TCGA patient cohorts, MUC16 protein abundance is significantly associated with the RNA expression of many other genes, with 6,649 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MUC16-associated genes across cancer lineages are SLPI, PLEKHS1, and CP. Each is linked with MUC16 in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC16-to-partner and partner-to-MUC16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MUC16 versus SLPI in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC16→partner) and Y-score (partner→MUC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLPI →	+1.788	+0.679	<.001	<.001	3	5
UCEC	PLEKHS1 →	+1.933	+1.079	<.001	<.001	3	5
LSCC	CP →	+2.227	+1.431	<.001	<.001	3	5
LSCC	WFDC2 →	+2.353	+1.457	<.001	<.001	3	4
LUAD	RHOV →	+1.408	+1.126	<.001	<.001	3	4
LUAD	TCN1 →	+2.074	+1.141	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,649 associations by consensus.

MUC16 vs SLPI — BRCA

Explore this scatter interactively →