MUC16

Across TCGA patient cohorts, MUC16 mutation is significantly associated with the RNA expression of many other genes, with 16,278 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MUC16-associated genes across cancer lineages are LIMS2, PBK, and TIMM44. Each is linked with MUC16 in more than 10 cancer types. Because this analysis shows association rather than direction, both MUC16-to-partner and partner-to-MUC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIMS2 grouped by MUC16-low versus MUC16-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC16→partner) and Y-score (partner→MUC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	LIMS2 →	-0.724	-1.750	<.001	<.001	3	11
STAD	PBK →	+0.812	+1.403	<.001	<.001	3	11
UCEC	TIMM44 →	+0.309	+1.032	<.001	<.001	3	10
GBM	TWIST2 →	-0.739	-3.807	.001	<.001	3	10
LIHC	PTH1R →	-0.415	-1.066	.004	.004	2	11
LIHC	SORCS2 →	-0.517	-1.163	.003	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,278 associations by consensus.

LIMS2 by MUC16 expression — STAD

Explore this box plot interactively →