MUC16

Across TCGA patient cohorts, MUC16 mutation is significantly associated with the total protein of many other genes, with 146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC16-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and Cyclin-B1. Each is linked with MUC16 in more than 8 cancer types. Because this analysis shows association rather than direction, both MUC16-to-partner and partner-to-MUC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MUC16-low versus MUC16-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC16→partner) and Y-score (partner→MUC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.567	+1.174	<.001	.004	3	9
PRAD	Caveolin-1 →	-0.701	-3.321	.005	.009	3	9
READ	Cyclin-B1 →	+0.489	+3.321	.015	.005	3	7
READ	c-Kit →	-0.693	-2.502	.001	.001	3	6
LUAD	MIG-6 →	+0.094	+0.668	.009	.013	3	6
UCEC	4E-BP1 →	+0.260	+0.940	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

Caspase-7-cleavedD198 by MUC16 expression — COAD

Explore this box plot interactively →