MUC16

Across TCGA cell cohorts, MUC16 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,758 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible MUC16-associated GO terms across cancer lineages are Regulation of ruffle assembly, Viral process, and Response to indole-3-methanol. Each is linked with MUC16 in more than 8 cancer types. Because this analysis shows association rather than direction, both MUC16-to-partner and partner-to-MUC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ruffle assembly grouped by MUC16-low versus MUC16-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC16→partner) and Y-score (partner→MUC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of ruffle assembly →	+0.163	+2.654	.001	.001	3	9
STOMACH	Viral process →	+0.063	+1.681	.001	.003	3	8
LUNG_NSCLC_LUAD	Response to indole-3-methanol →	+0.179	+2.526	<.001	<.001	3	8
STOMACH	Small GTPase-mediated signal transduction →	+0.060	+2.180	<.001	.004	3	8
STOMACH	Regulation of protein modification by small protein conjugation or removal →	+0.071	+2.637	<.001	<.001	3	8
STOMACH	Cell-substrate junction assembly →	+0.148	+1.809	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

Regulation of ruffle assembly by MUC16 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →