MUC16

Across TCGA cell cohorts, MUC16 mutation is significantly associated with the RNA expression of many other genes, with 1,686 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MUC16-associated genes across cancer lineages are CFAP300, CYBRD1, and SLC66A3. Each is linked with MUC16 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC16-to-partner and partner-to-MUC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFAP300 grouped by MUC16-low versus MUC16-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC16→partner) and Y-score (partner→MUC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CFAP300 →	-1.238	-2.169	.002	.008	3	4
BLOOD_Leukemia	CYBRD1 →	-0.687	-1.706	.005	.001	3	4
CNS	SLC66A3 →	-0.503	-1.295	.003	<.001	3	4
SKIN	ZNF697 →	+1.168	+0.552	.004	.008	3	3
KIDNEY	CHEK1 →	+0.571	+2.115	.003	.001	3	3
SOFT_TISSUE	REEP2 →	-1.175	-1.912	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,686 associations by consensus.

CFAP300 by MUC16 expression — KIDNEY

Explore this box plot interactively →