MUC15

Across TCGA patient cohorts, MUC15 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC15-associated genes across cancer lineages are TFRC, A-Raf_pS299, and ACC1. Each is linked with MUC15 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC15-to-partner and partner-to-MUC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MUC15-low versus MUC15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC15→partner) and Y-score (partner→MUC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.606	+2.906	<.001	.001	3	4
UCEC	A-Raf_pS299 →	-0.174	-2.584	<.001	<.001	3	2
UCEC	ACC1 →	+0.269	+1.887	.027	.029	3	2
UCEC	MEK1 →	+0.434	+2.807	<.001	<.001	3	2
UCEC	MSH2 →	-0.201	-1.674	.009	.040	3	2
UCEC	p62 Lck ligand →	+0.272	+1.687	.012	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

TFRC by MUC15 expression — UCEC

Explore this box plot interactively →