MUC15

Across TCGA pan-cancer cohorts, MUC15 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MUC15 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MUC15 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MUC15 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CESC show a favorable association.

LUAD, KIRC, and STAD are the cancer types where MUC15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.802	0.556	.002	75	view →
KIRC	OS	Tertile	II,III,IV	0.722	0.904	<.001	67	view →
STAD	DFS	Quartile	II,III,IV	0.285	0.564	.001	58	view →
BLCA	OS	Tertile	II,III,IV	0.628	0.768	.001	52	view →
UVM	DFS	Tertile	All	0.228	0.630	.005	45	view →
COAD	DFS	Tertile	IV	0.270	0.615	<.001	44	view →
CESC	OS	Tertile	II,III,IV	0.927	0.709	.002	40	view →
UCEC	DFS	Median	All	0.573	0.723	<.001	38	view →
HNSC	OS	Median	All	0.789	0.710	.009	26	view →
DLBC	DFS	Median	III,IV	0.196	0.862	.008	24	view →
PCPG	DFS	Median	All	0.978	0.869	.002	22	view →
GBM	OS	Tertile	All	0.162	0.465	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MUC15–LUAD (DFS)

Open the LUAD breakdown →