MUC13

Across TCGA patient cohorts, MUC13 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC13-associated genes across cancer lineages are FoxM1, ATM, and 53BP1. Each is linked with MUC13 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC13-to-partner and partner-to-MUC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MUC13-low versus MUC13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC13→partner) and Y-score (partner→MUC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.253	+2.584	.010	.001	3	3
UCEC	ATM →	-0.376	-3.169	.030	.019	3	2
UCEC	53BP1 →	+0.297	+2.000	.023	.030	3	2
UCEC	14-3-3_beta →	-0.108	-2.432	.005	.018	3	1
UCEC	EGFR_pY1068 →	-0.262	-2.087	.006	.005	3	1
UCEC	A-Raf_pS299 →	-0.131	-3.700	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by MUC13 expression — UCEC

Explore this box plot interactively →