MUC13

Across TCGA pan-cancer cohorts, MUC13 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MUC13 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MUC13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MUC13 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

MESO, LUAD, and SCLC are the cancer types where MUC13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.283	0.483	<.001	101	view →
LUAD	DFS	Quartile	II,III,IV	0.583	0.779	.006	54	view →
SCLC	OS	Tertile	All	0.824	0.553	.002	34	view →
SKCM	OS	Median	III,IV	0.633	0.217	<.001	31	view →
STAD	OS	Quartile	All	0.634	0.365	.001	27	view →
ACC	DFS	Tertile	II,III,IV	0.256	0.707	.010	24	view →
UCEC	DFS	Median	All	0.931	0.862	.002	24	view →
THCA	DFS	Tertile	II,III,IV	0.765	0.965	<.001	24	view →
LGG	DFS	Median	All	0.312	0.478	.001	24	view →
ESCA	OS	Median	All	0.617	1.000	.009	18	view →
COAD	OS	Tertile	IV	0.797	0.377	.012	12	view →
BLCA	DFS	Quartile	III,IV	0.199	0.391	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MUC13–MESO (OS)

Open the MESO breakdown →