MUC13

Across TCGA cell cohorts, MUC13 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC13-associated genes across cancer lineages are TGIF2LY, MOGAT1, and TLX3. Each is linked with MUC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC13-to-partner and partner-to-MUC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGIF2LY grouped by MUC13-low versus MUC13-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC13→partner) and Y-score (partner→MUC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TGIF2LY →	+0.148	+4.736	<.001	.009	3	1
LARGE_INTESTINE	MOGAT1 →	+0.161	+3.878	<.001	.003	3	1
LARGE_INTESTINE	TLX3 →	+0.432	+3.453	.002	.009	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.148	+3.626	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TGIF2LY by MUC13 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →