MTX1

Across TCGA patient cohorts, MTX1 mutation is significantly associated with the RNA expression of many other genes, with 695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTX1-associated genes across cancer lineages are NMBR-AS1, MIR588, and RN7SKP43. Each is linked with MTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTX1-to-partner and partner-to-MTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMBR-AS1 grouped by MTX1-low versus MTX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTX1→partner) and Y-score (partner→MTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NMBR-AS1 →	+0.174	+4.513	<.001	.009	3	2
LUAD	MIR588 →	+0.519	+5.631	<.001	.004	3	2
COAD	RN7SKP43 →	+0.345	+6.734	<.001	<.001	3	2
CESC	NPM1P10 →	+0.072	+3.705	<.001	.008	3	2
UCEC	IGHD2-2 →	+1.207	+1.913	<.001	.001	3	2
UCEC	MIR1227 →	+0.250	+2.124	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 695 associations by consensus.

NMBR-AS1 by MTX1 expression — SKCM

Explore this box plot interactively →