MTSS1

Across TCGA patient cohorts, MTSS1 mutation is significantly associated with the RNA expression of many other genes, with 2,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTSS1-associated genes across cancer lineages are RN7SL248P, RN7SL785P, and LINC00458. Each is linked with MTSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTSS1-to-partner and partner-to-MTSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by MTSS1-low versus MTSS1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTSS1→partner) and Y-score (partner→MTSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL248P →	+0.159	+6.584	<.001	<.001	3	2
SKCM	RN7SL785P →	+0.138	+3.362	<.001	.006	3	2
UCEC	LINC00458 →	+0.119	+1.175	.002	.004	3	2
UCEC	EDC3 →	+0.209	+1.606	.005	<.001	3	2
UCEC	RAD23A →	+0.320	+1.771	.003	<.001	3	2
UCEC	GINS3 →	+0.505	+2.343	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

RN7SL248P by MTSS1 expression — CESC

Explore this box plot interactively →