MTRNR2L4

Across TCGA cell cohorts, MTRNR2L4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,056 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MTRNR2L4-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Negative regulation of mRNA splicing, via spliceosome, and mRNA splice site recognition. Each is linked with MTRNR2L4 in more than 9 cancer types. Because this analysis shows association rather than direction, both MTRNR2L4-to-partner and partner-to-MTRNR2L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by MTRNR2L4-low versus MTRNR2L4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRNR2L4→partner) and Y-score (partner→MTRNR2L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.153	+0.163	.001	.005	3	10
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.094	+0.169	.002	.004	3	10
BREAST	mRNA splice site recognition →	+0.101	+0.247	<.001	.001	3	10
SKIN	Cytosolic transport →	+0.074	+0.143	<.001	<.001	3	9
BONE	Negative regulation of RNA splicing →	+0.066	+0.122	.004	.004	3	9
BONE	Negative regulation of mRNA processing →	+0.090	+0.169	.002	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,056 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by MTRNR2L4 expression — BONE

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