MTRNR2L4

Across TCGA pan-cancer cohorts, MTRNR2L4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MTRNR2L4 data layer.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MTRNR2L4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MTRNR2L4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

SCLC, STAD, and HNSC are the cancer types where MTRNR2L4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.619	0.231	<.001	88	view →
STAD	DFS	Median	III,IV	0.465	0.679	.002	53	view →
HNSC	OS	Median	IV	0.510	0.341	.003	50	view →
ACC	DFS	Tertile	II,III,IV	0.661	0.129	.005	47	view →
DLBC	DFS	Median	II,III,IV	0.517	1.000	.011	40	view →
BLCA	OS	Tertile	All	0.190	0.500	.008	36	view →
LUSC	DFS	Median	All	0.804	0.714	.007	21	view →
READ	OS	Median	All	0.735	0.558	.017	13	view →
UVM	DFS	Median	III,IV	0.372	0.670	.014	12	view →
LAML	DFS	Tertile	All	0.533	0.355	.017	10	view →
LUAD	DFS	Median	III,IV	0.503	0.164	.005	10	view →
TGCT	DFS	Tertile	All	0.936	0.723	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MTRNR2L4–SCLC (OS)

Open the SCLC breakdown →