MTREX

Across TCGA patient cohorts, MTREX mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTREX-associated genes across cancer lineages are p53, eIF4E, and p62 Lck ligand. Each is linked with MTREX in more than 1 cancer types. Because this analysis shows association rather than direction, both MTREX-to-partner and partner-to-MTREX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by MTREX-low versus MTREX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTREX→partner) and Y-score (partner→MTREX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p53 →	+0.428	+2.820	<.001	.035	3	2
UCEC	eIF4E →	+0.154	+2.598	.029	.005	3	2
UCEC	p62 Lck ligand →	+0.306	+2.807	.004	.002	3	2
UCEC	ATM →	-0.486	-1.584	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.203	-2.415	.015	.003	3	1
UCEC	JNK2 →	+0.200	+1.874	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p53 by MTREX expression — SKCM

Explore this box plot interactively →