MTREX

Across TCGA cell cohorts, MTREX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,769 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTREX-associated GO terms across cancer lineages are Positive regulation of rRNA processing, Transcription initiation at RNA polymerase I promoter, and Protein localization to chromosome. Each is linked with MTREX in more than 15 cancer types. Because this analysis shows association rather than direction, both MTREX-to-partner and partner-to-MTREX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by MTREX-low versus MTREX-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTREX→partner) and Y-score (partner→MTREX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of rRNA processing →	+0.154	+0.785	<.001	<.001	3	16
OESOPHAGUS	Transcription initiation at RNA polymerase I promoter →	+0.105	+0.895	.003	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome →	+0.104	+0.947	<.001	.001	3	15
BONE	Maturation of SSU-rRNA →	+0.142	+0.691	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	RNA export from nucleus →	+0.108	+0.788	.002	.004	3	14
SOFT_TISSUE	DNA-templated transcription elongation →	+0.074	+0.818	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,769 associations by consensus.

Positive regulation of rRNA processing by MTREX expression — LARGE_INTESTINE

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