MTREX

Across TCGA cell cohorts, MTREX mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTREX-associated genes across cancer lineages are SERPINA7, C1orf158, and KRTAP3-2. Each is linked with MTREX in more than 1 cancer types. Because this analysis shows association rather than direction, both MTREX-to-partner and partner-to-MTREX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by MTREX-low versus MTREX-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTREX→partner) and Y-score (partner→MTREX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP3-2 →	+0.943	+4.807	.001	.006	3	1
BLOOD_Lymphoma	BMX →	+1.206	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	DEFB129 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	MROH2B →	+0.063	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

SERPINA7 by MTREX expression — BLOOD_Myeloma

Explore this box plot interactively →