MTRES1

Across TCGA patient cohorts, MTRES1 mutation is significantly associated with the RNA expression of many other genes, with 836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRES1-associated genes across cancer lineages are RBM48P1, COPRSP1, and LINC00459. Each is linked with MTRES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRES1-to-partner and partner-to-MTRES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM48P1 grouped by MTRES1-low versus MTRES1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRES1→partner) and Y-score (partner→MTRES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBM48P1 →	+0.064	+4.516	<.001	.009	3	2
BLCA	COPRSP1 →	+0.126	+5.017	<.001	.002	3	2
SKCM	LINC00459 →	+0.107	+5.594	<.001	.004	3	2
UCEC	PGAP2 →	+0.477	+3.716	.001	<.001	3	1
UCEC	MAT1A →	-0.954	-2.906	.002	.002	3	1
UCEC	VPS26B →	+0.423	+3.354	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

RBM48P1 by MTRES1 expression — COAD

Explore this box plot interactively →