MTRES1

Across TCGA pan-cancer cohorts, MTRES1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MTRES1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MTRES1 RNA is repressed in tumor relative to normal tissue. In most cancer types MTRES1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRP are the cancer types where MTRES1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTRES1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.895	<.001	10	view →
THCA	Male	II,III,IV	−0.790	<.001	9	view →
KIRP	Female	All	−0.539	<.001	9	view →
KIRC	Male	II,III,IV	−0.483	<.001	7	view →
LIHC	All	All	+0.339	<.001	7	view →
LUSC	Female	All	+0.710	<.001	6	view →
COAD	All	All	−0.429	<.001	5	view →
LUAD	All	All	+0.263	.001	4	view →
CHOL	All	II,III,IV	+1.045	.028	3	view →
STAD	All	All	+0.411	.008	3	view →
ESCA	All	II,III,IV	+0.779	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MTRES1–KICH

Open the KICH breakdown →