MTRES1

Across TCGA patient cohorts, MTRES1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRES1-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and INPP4B. Each is linked with MTRES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRES1-to-partner and partner-to-MTRES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MTRES1-low versus MTRES1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRES1→partner) and Y-score (partner→MTRES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.154	-3.169	.005	.019	3	1
UCEC	FoxM1 →	+0.250	+2.179	.038	.034	3	1
UCEC	INPP4B →	-0.377	-3.321	.012	.009	3	1
UCEC	Paxillin →	+0.317	+2.179	.008	.034	3	1
UCEC	PRAS40_pT246 →	+0.198	+1.887	.013	.031	3	1
UCEC	Tuberin →	+0.457	+2.179	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

A-Raf_pS299 by MTRES1 expression — UCEC

Explore this box plot interactively →