MTPN

Across TCGA pan-cancer cohorts, MTPN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MTPN data layer compared with 30 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MTPN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MTPN expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where MTPN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.211	0.839	.001	18	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	13	view →
COAD	DFS	Quartile	II,III,IV	0.850	1.000	.039	6	view →
GBM	OS	Quartile	All	0.592	0.947	.026	6	view →
HNSC	OS	Tertile	All	0.919	0.768	.043	2	view →
LSCC	OS	Median	All	0.793	1.000	.025	2	view →
PDAC	DFS	Median	All	0.813	0.712	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MTPN–LUAD (OS)

Open the LUAD breakdown →