MTPN

Across TCGA pan-cancer cohorts, MTPN mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTPN’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MTPN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MTPN is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where MTPN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTPN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.499	<.001	12	view →
COAD	All	III,IV	−0.325	<.001	10	view →
LUAD	All	III,IV	−0.299	<.001	9	view →
HNSC	Male	III,IV	−0.187	.001	8	view →
PDAC	All	All	+0.393	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MTPN–CCRCC

Open the CCRCC breakdown →