MTO1

Across TCGA patient cohorts, MTO1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTO1-associated genes across cancer lineages are Ku80, AMPK_pT172, and Rab11. Each is linked with MTO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTO1-to-partner and partner-to-MTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MTO1-low versus MTO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTO1→partner) and Y-score (partner→MTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.233	+2.598	.034	.006	3	1
UCEC	AMPK_pT172 →	+0.514	+3.713	.007	<.001	3	1
UCEC	Rab11 →	-0.184	-2.584	.006	.011	3	1
UCEC	Rictor_pT1135 →	-0.111	-3.169	.020	.018	3	1
UCEC	SETD2 →	-0.200	-2.584	.048	.011	3	1
UCEC	STAT3_pY705 →	-0.340	-2.311	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Ku80 by MTO1 expression — UCEC

Explore this box plot interactively →